City of Heroes on Mac
There are various ways to operate the Game Client on the Apple Macintosh.
- Main Article: Mac Special Edition
Mac Special Edition was made possible using TransGaming's Cider Portability Engine, which acts as a "wrapper" around the game software, enabling it to run seamlessly on Intel-based Macs running Mac OS X.
November 7, 2008, saw the beginning of the Mac Client's closed beta testing. 
Running City of Heroes through Boot Camp is exactly like running it under Windows. Because it is running it under Windows. Boot Camp is Apple's officially supported method of Dual Booting a Mac computer.
Prior to the Mac Game Client, Boot Camp was the preferred method of running City of Heroes as there were no extra emulation layers.
The standard comments about using Windows Vista apply.
After you've installed/patched Windows on your Boot Camp partition, you can copy the client from an existing installation location or DVD, or grab the updater and download the current version.
Read all about the Windows Game Client here.
Boot Camp Links
Parallels Desktop for Mac is a piece of Virtualization software. It allows a second "guest" operating system to run along side the main "host" operating system. The later versions includes limited hardware video card support. In Parallels 4, up to 256MB of memory can be set aside just for the emulated video card. Some applications are able to smoothly utilize this video card.
- Unsuccessful test; graphical issues surrounding the cursor, even in fullscreen mode. Didn't bother entering the game because I couldn't click on things reliably. Wait for the native client. ;-) - @Ex-calibur
Overview of running under VMWare Fusion.
VMWare Fusion Links
Overview on running under WINE/Wine.
CrossOver Games for Mac
Overview on running under CrossOver/CrossOver Games.
City of Heroes runs perfectly well under CrossOver Games version 7.1.1 (but is not 7.2.0). There is a known bug in Crossover Games 7.2.0 that prevents it from going past the click "Next" screen.
However the game runs brilliantly well under CrossOver Games 7.1.1.
Simply download the COHUpdate.exe file (from ftp://client.coh.com/ ) and install it under a WinXP bottle inside CrossOver, and that's all there is to it.