This rune is a relic of the Legacy Chain. When an unsuspecting villain crosses one, it self destructs and applies a Damage and Tohit debuff for 60 seconds to everyone nearby. The rune is also targetable and has the same Hit Points as a Minion of the same level. Apparently, if the rune is attacked and its life bar drops to 50% the rune will self destruct.
The Isa Runes are found:
- In the the Find info on coral key mission from Operative Renault, on the Operative Renault Strike Force.
These strange runes glow ominously with unstable mystic energy.